A key component to managing the Covid-19 pandemic is frequent, rapid, and routine testing of a large number of Americans — including those without symptoms. With public discussion of this issue has come increased scrutiny of the accuracy of Covid-19 tests, especially the rapid point-of-care tests whose results can come back in a matter of minutes.
Yet these discussions rarely explain what test accuracy actually means, and how it should be used in clinical decision-making. Without this understanding, it is impossible to make truly informed decisions about whether and how these rapid point-of-care tests should be used. And the focus on accuracy obscures an important point: even tests that aren’t perfect can play important roles in controlling this pandemic.
Fortunately, there is a precise way to evaluate the accuracy and interpretation of tests like these. Called Bayes’ Theorem, it can help make sense of the current situation by showing us that the usefulness of a test depends not just on how accurate it is but also on how likely someone is to have the condition it is testing for.
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Test characteristics are usually reported in terms of their sensitivity and specificity. Sensitivity, sometimes called the true positive rate, tells you what percentage of people who have the disease you are testing for (like Covid-19) will test positive. Specificity, sometimes called the true negative rate, tells you what percentage of people who don’t have the disease will test negative.
In other words, in a theoretical group of 100 people infected with SARS-CoV-2, the virus that causes Covid-19, how many would have a positive test? And in a theoretical group of 100 people not infected with the virus, how many of would have a negative Covid-19 test?
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That is all well and good, but in the real world we don’t have 100 theoretical people known to be with or without Covid-19. That’s what we’re trying to find out. Instead, what we have are 100 people with positive or negative test results, and we need to know whether or not they really have the disease based on the testing that they’ve had.
The answers to these questions are known as the positive predictive value (PPV) and the negative predictive value (NPV). The positive predictive value represents this: Of 100 people with positive tests, how many of them actually have the disease? The negative predictive value is analogous: Of 100 people with negative tests, how many of them do not have the disease.
Here’s how they are different from sensitivity and specificity: Sensitivity and specificity start with people with and without the disease — which we don’t know — while the positive predictive value and negative predictive value start with people with positive or negative test results — which we do know.
The complicating factor is that positive predictive values and negative predictive values are not just dependent on the characteristics of the test (the sensitivity and specificity) but also on how likely someone is to have the disease in the first place, known as the pretest probability. This is the crucial message of Bayes’ theorem, and it’s key to understanding how to interpret the usefulness of a test and how — and how often — the test should be used.
We put all these concepts together with two examples: the first with a low pre-test probability, the second with high pre-test probability. For both examples, let’s set the sensitivity of a rapid point-of-care Covid-19 test at 80%, with a specificity of 100%, reasonable estimates for these sorts of tests. Some criticize the rapid tests for low sensitivity, with people understandably worried that it will miss too many cases. As we’ll show, that can be a problem, but it isn’t always.
In the first example with low pre-test probability, say 1,000 people who feel fine — they are completely asymptomatic — are tested for Covid-19. Such testing is important because people without symptoms can transmit the disease, especially if they become sick soon after. This is the kind of testing proposed for some students entering school, for some employees returning to in-person work, and for entering the state of Maine.
In Massachusetts, where we live and work and where the disease is currently under good control, the pre-test probability in asymptomatic people is low — certainly no higher than 1%.
Do the math using Bayes’ Theorem (you can see it laid out here), and approximately eight of these 1,000 people will have positive rapid tests. All eight will have Covid-19: the positive predictive value is 100%. Of the 992 with negative tests, 990 of them will not have Covid-19 and two of them will: the negative predictive value is 99.8% (990 divided by 992). In other words, if you have a rapid test for Covid-19 and it is negative, you have 2 in a 1,000 chance of actually having — and potentially spreading — the disease. This is a small enough chance to let you attend school, go to work, or visit Maine.
And even though the test isn’t perfect, it’s far better than what we’re doing now, which is testing hardly anyone without symptoms, in part due to concerns about testing accuracy. A rapid, inexpensive Covid-19 test, even one with lower sensitivity — like 80%, meaning it misses 20% of cases — would be a true advance in our efforts to control the pandemic. And there’s this to consider: Those who are most infectious have the highest amount of virus and are the least likely to have falsely negative rapid tests.
On to the second example, among those with a high pre-test probability: 1,000 patients with signs or symptoms of Covid-19, such as fever or shortness of breath. Let’s say the pre-test probability here is 30%, as it was during the surge of cases in Massachusetts this spring.
Do the math using Bayes’ Theorem and the positive predictive value remains at 100% (240 out of 240 with a positive test), but the negative predictive value has dropped to 92% (700 of the 760 with a negative test). Now it’s time to worry about low sensitivity: 8% of those with negative tests actually have Covid-19. That is too high, and it’s why symptomatic patients at our hospital are tested twice —using the most accurate tests available — 24 hours apart, with additional testing if we’re really suspicious.
Applying Bayes’ theorem to Covid-19 testing has several implications for controlling the pandemic. First, even tests with moderate sensitivity, like the current rapid point-of-care tests, are good enough when the pre-test probability of those being tested is low, such as among asymptomatic people in states with low rates of community spread. These tests will be crucial tools for getting back to work and school safely, and arguably attainable even before we have a safe vaccine.
Second, these tests work best when the rate of community transmission is low, as the low pre-test probability means that few cases will be missed. This is one of several reasons why expert recommendations for phased re-opening recommend first getting the disease under control (with a combination of stay-at-home orders and recommendations for physical distancing and wearing face coverings in public) and only then initiating testing on a massive scale for screening and contact tracing.
Third, individuals with symptoms of Covid-19 should be given the most sensitive tests available. As their pre-test probability is high, they may need to be tested twice, or undergo other testing strategies (such as antibody testing, or PCR testing of sputum samples) to ensure they do not have Covid-19.
The goal at this point should be to pursue testing strategies that are rapid, convenient, accessible, and inexpensive. That way a large proportion of the population can be tested. A small decline in the accuracy of Covid-19 tests is less important at this point than our need for testing on a massive scale.
Jeffrey L. Schnipper is an internal medicine physician, research director of the Division of General Internal Medicine and Primary Care at Brigham and Women’s Hospital in Boston, and professor of medicine at Harvard Medical School. Paul E. Sax is an infectious disease physician, clinical director of the Division of Infectious Diseases at Brigham and Women’s Hospital, and professor of medicine at Harvard Medical School.
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August 20, 2020 at 03:58PM
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Even imperfect Covid-19 tests can help control the pandemic - STAT
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